QuickView for protease e;jsessionid=95A95E084DC27F53D8E818A09001581A;jsessionid=48ACD673B48ECC48DFEE2D5FA9DB1F80 (gene)

Gene Symbol:

CELA3B Homo sapiens

Full name:

chymotrypsin like elastase family member 3B

Synonyms:

CBPP, ELA3B, chymotrypsin-like elastase family member 3B, cholesterol-binding pancreatic protease, elastase 3B, pancreatic, elastase IIIB, elastase-3B, fecal elastase 1, pancreatic elastase 1, pancreatic endopeptidase E, protease E, proteinase E

Genomic Location:

Chr 1: 22176005-22188434

Description:

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the p...

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Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MYOD_Q6_01 ,  MYOD_01 ,  E2A_Q2 ,  GATA1_04 ,  TAL1BETAE47_01 ,  CAGGTG_E12_Q6 ,  GATA1_05

Cytogenetic Map:

1p36.12

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